Hyposmia as a marker of (non-)motor disease severity in Parkinson’s disease
نویسندگان
چکیده
منابع مشابه
A Marker of Disease Severity?
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متن کاملIdiopathic hyposmia as a preclinical sign of Parkinson's disease.
Olfactory dysfunction is an early and common symptom in Parkinson's disease (PD). In an effort to determine whether otherwise unexplained (idiopathic) olfactory dysfunction is associated with an increased risk of developing PD, we designed a prospective study in a cohort of 361 asymptomatic relatives (parents, siblings, or children) of PD patients. A combination of olfactory detection, identifi...
متن کاملStriatal Dopamine Depletion Patterns and Early Non-Motor Burden in Parkinsons Disease
BACKGROUND The mechanism underlying non-motor symptoms in Parkinson's disease has not yet been elucidated. In this study, we hypothesized that Parkinson patients with more non-motor symptoms have a different pattern of striatal dopamine depletion, particularly in areas other than the sensorimotor striatum, compared to those with fewer non-motor symptoms. METHODS We conducted a prospective sur...
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ژورنال
عنوان ژورنال: Journal of Neural Transmission
سال: 2019
ISSN: 0300-9564,1435-1463
DOI: 10.1007/s00702-019-02074-0